For a while now, Sulforaphane has been a hot topic within the scientific community. Its received particular attention from Rhonda Patrick and Tim Ferriss. Whilst it can consumed via broccoli sprouts, these aren’t always easy or convenient to consume. The below post discusses the best supplement options.
Jed Fahey, one of the leading researchers in the field, warns us to be careful of which supplement we use. Saying their lab, which has analyzed dozens of supplements over the years, has found that many are terrible, and don’t contain what they say they do.
To complicate matters, there are 3 main ways to consume sulforaphane:
- Pure Sulforaphane – Average bioavailability of 70%*
- Glucoraphanin + Myrosinase – Average bioavailability of 35%*
- Glucoraphanin – Average bioavailability of 10%*
* Bioavailability numbers come from Jed Fahey’s research at John Hopkins. See source #3 below for more info.
Below are a list of the best sulforaphane supplements. All are currently used by Jed Fahey’s team at John Hopkins University in their clinical studies:
Consuming active sulforaphane itself has the greatest potential affect (measured using a term called bioavailability). Currently, there is only one free-form stabilized sulphoraphane product on the market. Its name is Prostaphane, and is manufactured in France by a company called Nutrinov.
You may see products advertising that they contain Sulforaphane (specifically Sulforaphane Glucosinolate), however, it should be noted that this is misleading. Whilst it is technically accurate to say that they contain the glucosinolate form of sulforaphane, actually they contain glucoraphanin. It then needs to be converted into sulforaphane via myrosinase.
The next best alternative to active sulforaphane is consuming the precursor glucoraphanin alongside the activation enzyme myrosinase.
Avmacol is a high end supplement made by Nutramax Laboratories. It is glucoraphanin extracted from Broccoli seeds, plus the active myrosinase enzyme.
Each Avmacol pack contains 60 tablets, which at 2 tablets per day, is a 1 months supply.
Crucera-SGS is a supplement from Thorne Research containing concentrated glucoraphanin.
Crucera-SGS comes in 60 tablet packs, doses at 1 tablet per day, so 2 months supply.
As briefly mentioned above, although the supplement ingredients read “Sulforaphane Glucosinolate”, this isn’t to be confused with active sulforaphane (found in prostaphane). Sulforaphane Glucosinolate is actually Glucoraphanin, before it has been transformed by the enzyme myrosinase, into sulforaphane.
- All 3 supplements mentioned above are currently used in clinical trials by John Hopkins University. This means that they’ve been tested and confirmed to contain what they say.
- The most bioavailable sulforaphane supplement you can buy is called prostaphane, but so far, is only distributed in France.
- Next most bioavailable (and accessible in the USA) is Avmacol, because it bundles the enzyme myrosinase alongside its glucoraphanin.
Sources for this article:
- Chemoprotection Center At John Hopkins University FAQ
- Jed Fahey Interview on Rhonda Patrick’s Podcast
- Further publications from John Hopkins University research
P.S. Check out this post on supplements that Rhonda Patrick takes – these can make good additions to sulforaphane.